Science Programme

Life Sciences 2007: 8-12 July 2007 at the SECC, Glasgow, UK Life Sciences 2007 is the first joint meeting of the Biochemical Society, the British Pharmacological Society and The Physiological Society.

Plenary speakers

Due to high demand Plenary lectures will be ticketed. If you wish to attend please make sure that this is indicated on your registration form

Monday 9 July 2007 14:00-15:00
Tony Pawson  (Samuel Lunenfeld Research Institute, Toronto, Canada) The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
This Award Lecture will be published in Biochemical Society Transactions
Chair: Melanie Welham (University of Bath, UK)
Tuesday 10 July 2007 08:30-09:30
Denis Noble  (University of Oxford, UK) The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Tuesday 10 July 2007 13:30-14:30
Michael Joyner  (Mayo Clinic College of Medicine, USA) The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Wednesday 11 July 2007 08:30-09:30
Arthur Christopoulos  (Monash University, Victoria, Australia) The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Wednesday 11 July 2007 13:30-14:30
Thomas Bolton  (St Georges Hospital, London, UK) The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Thursday 12 July 2007 08:30-09:30
Michael Stratton  (Wellcome Trust Sanger Institute, Cambridge, UK) The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
This Award Lecture will be published in Biochemical Society Transactions
Chair: Peter Parker (Cancer Research UK)
Thursday 12 July 2007 14:00-15:00
Frank Sargent  (University of East Anglia, UK) The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
This Award Lecture will be published in Biochemical Society Transactions
Chair: Stuart Ferguson (University of Oxford, UK)



Focus Topic: Promega UK Young Life Scientist Competition


Promega UK Young Life Scientist Award - The finalists

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
15:30-16:30 Poster session
Speakers
16:30-16:45 Lucy Norling (William Harvey Research Institute, London, UK)
Endothelial galectin-1 is a novel determinant of endogenous anti-inflammation
16:45-17:00 Talitha Kerrigan (University of Leeds, UK)
Calsenilin regulates Amyloid-â formation and transient ‘A’-type current through Kv4.2 subunits
17:00-17:15 Ioannis Smyrnias (The Babraham Institute, Cambridge, UK)
Subcellular distribution of key proteins involved in endothelin-1-induced arrhythmia and inotropy in adult rat ventricular myocytes (ARVMs)
17:15-17:30 Fabien Brette (University of Manchester, UK)
Electrophysiological characteristics of freshly isolated ventricular myocytes from Zebrafish (Dario rerio)
17:30-17:45 Mayowa Osundiji (University of Cambridge, UK)
Hypothalamic glucokinase plays a critical role in the regulation of protective feeding to glucoprivation
17:45-18:00 Ferhana Ali (Imperial College London, UK)
Characterisation of the pro-aggregatory effects of gram positive or gram negative bacteria in human platelet rich plasma


Focus Topic: GPCR


A day in the life of a GPCR

Wednesday 11 July 2007

Organizer(s)
Graeme Henderson (University of Bristol, UK)
Stuart Mundell (University of Bristol, UK)
Speakers
09:30-10:00 Graeme Milligan (University of Glasgow, UK)
The quaternary structure of G protein-coupled receptors: a day in the life
10:00-10:30 Martin Lohse (University of Wurzburg, Germany)
Kinetic analysis of GPCR-mediated signalling events
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Marco Parenti (University of Milano-Bicocca, Italy)
Coupling of seven-transmembrane receptors with G15 protein challenges the paradigm of desensitization
11:15-11:30 Selected oral communication - Geneviève Laroche (University of Sherbrooke, Quebec, Canada)
Arrestin-3 interacts with specific Ga proteins and COPI, and regulates export of G protein-coupled receptors
11:30-12:00 Eamonn Kelly (University of Bristol, UK)
At the end of the day, receptors get tired too
12:00-12:30 Mark Von Zastrow (University of California, San Francisco, USA)
Mechanisms and consequences of GPCR sorting in the endocytic pathway
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Emerging roles for proteinase-activated receptors in health and disease

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Organizer(s)
William Ferrell (University of Glasgow, UK)
John Lockhart (Paisley University, UK)
Robin Plevin (Strathclyde University, UK)
Trevor Bushell (Strathclyde University, UK)
Speakers
14:30-15:00 Morley Hollenberg (University of Calgary, Canada)
Proteinases and signalling - to PAR or Bogey: pathophysiological and therapeutic implications via PARs and more
15:00-15:30 Kathryn DeFea (University of California, Oakland, USA)
b-arrestin-dependent, G-protein-independent PAR-2 signalling
15:30-16:30 Poster session
16:30-17:00 Atsufumi Kawabata (Kinki University, Higashi-Osaka, Japan)
Gastrointestinal roles for proteinase-activated receptors
17:00-17:30 Rachel Chambers (University College London, UK)
The role of proteinase-activated receptors in lung inflammation and fibrosis
17:30-17:45 Selected oral communication - Georg Reiser (Otto-von-Guericke University, Magdeburg, Germany)
A protease-activated receptor-2 (PAR-2)-interacting protein, Jab1, is involved in PAR-2-induced activation of AP-1, and PAR-2-induced release of chemokine GRO/CINC-1 from rat astrocytes via differential JNK activation protects brain tissue
17:45-18:00 Selected oral communication - Katerina Oikonomopoulou (University of Toronto, Ontario, Canada)
Kallikrein signalling: regulating inflammation via proteinase-activated receptors (PARs)

Lights, camera...GPCR!

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Andrew Irving (University of Dundee, UK)
Speakers
09:30-10:00 Rafael Franco (University of Barcelona, Spain)
GPCR heterodimers: function and ligand pharmacology
10:00-10:30 Carsten Hoffmann (University of Wuerzburg, Germany)
Novel methods for site-specific fluorescent labeling of GPCRs in living cells – use of a FLASH-light to look at GPCR activation
10:30-11:30 Poster session with coffee and tea
11:30-12:00 Maria Waldhoer (University of Graz, Austria)
Signalling and trafficking of virally encoded chemokine receptors
12:00-12:30 Andrew Tobin (University of Leicester, UK)
Novel aspects of GPCR regulation by phosphorylation
12:30-12:45 Selected oral communication - Suleiman Al-Sabah (University of Reading, UK)
Investigating activation of human G protein-coupled receptor kinase 2 by c-SRC, using site-directed mutagenesis and real-time FRET measurements
12:45-13:00 Selected oral communication - Dawn Thompson (Ernest Gallo Clinic and Research Center, California, USA)
GASP and the postendocytic sorting of the dopamine receptor family
13:00-14:00 Lunch, poster viewing and trade exhibition

Therapeutic potential of orphan GPCR research

Thursday 12 July 2007

13:00-14:00 Lunch, poster viewing and trade exhibition
14:00-15:00 Plenary Lecture
Frank Sargent (University of East Anglia, UK)
The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
Chair: Stuart Ferguson (University of Oxford, UK)
Organizer(s)
Alan Wise (GlaxoSmithKline, UK)
Sponsor(s)
GlaxoSmithKline
Speakers
15:00-15:30 Olivier Civelli (University of California, Irvine, USA)
Orphan GPCRs and the regulation of food intake
15:30-16:00 Stefan Offermanns (University of Heidelberg, Germany)
Nicotinic acid receptor - pharmacological and physiological functions
16:00-16:15 Selected oral communication - Yongxue Liu (Beijing Insititute of Radiation Medicine, Beijing, China)
Involvement of a-ketoglutarate receptor in diabetic nephropathy
16:15-16:30 Selected oral communication - Janet Maguire (University of Cambridge, UK)
Novel function of the inflammatory chemokine MIP1-b, a ligand for the HIV co-receptor CCR5, as a vasoconstrictor of human blood vessels: antagonism by maraviroc
16:30-17:00 Hilary Overton ((OSI) Prosidion, Oxford, UK)
GPR119: a receptor for oleoylethanolamide, and its potential role in diabesity
17:00-17:30 Peter Greasley (AstraZeneca R&D Mölndal, Sweden)
A new receptor for cannabinoid ligands


Focus Topic: Exercise


Xtreme-Everest

Monday 9 July 2007

Organizer(s)
Find out more by visiting the Xtreme-Everest website
Michael Grocott (University College London, UK)
Speakers
15:00-15:30 Michael Grocott (University College London, UK)
Xtreme-Everest: a field study of human adaptation to hypoxia
15:30-16:00 Mark Wilson (University College London, UK)
Neuroscience research at extreme altitude
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Damian Bailey (University of Glamorgan, UK)
Free radical exchange kinetics and pulmonary artery pressure response in high-altitude pulmonary oedema
16:45-17:00 Selected oral communication - Kevin Evans (University of Glamorgan, UK)
Exercise-induced arterial hypoxaemia is associated with a reduction in the systemic bioavailability of nitric oxide
17:00-17:30 Denny Levett (University College London, UK)
Cardiopulmonary exercise testing at extreme altitude
17:30-18:00 Daniel Martin (University College London, UK)
Oxygen delivery at high altitude

Mechanisms of diet and exercise induced protection from obesity and diabetes

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Peter Downes (University of Dundee, UK)
Peter Taylor (University of Dundee, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Merck Serono
Speakers
09:30-10:00 Grahame Hardie (University of Dundee, UK)
The AMP-activated protein kinase system – protecting cellular and whole body energy balance
10:00-10:30 Marc Montminy (The Salk Institute, La Jolla, USA)
The TORC family of CREB coactivators: regulators of energy balance
10:30-11:00 Coffee/tea break
11:00-11:30 Bruce Spiegelman (Harvard Medical School, Boston, USA)
PGC-1 coactivators and the control of energy homeostasis
11:30-12:00 Bente Pedersen (University of Copenhagen, Denmark)
The IL-6 signalling in exercise and disease: diabetes and inflammatory disease
12:00-12:15 Selected oral communication - James Timmons (Heriot Watt University, Edinburgh, UK)
Defining the essential mammalian endurance training transcriptome
12:15-12:30 Selected oral communication - Tantip Boonsong (University of Nottingham, UK)
Effect of exercise and insulin on SREBP-1c expression in human skeletal muscle: potential roles for the ERK1/2 and Akt signalling pathways
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Exercise and ageing

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Matthew Lancaster (University of Leeds, UK)
Sandra Jones (University of Leeds, UK)
Speakers
14:30-15:00 Ole Johan Kemi (University of Glasgow, UK)
Exercise training: the fountain of youth?
15:00-15:30 Anne McArdle (University of Liverpool, UK)
Age-related loss of skeletal muscle mass and function: mechanisms of prevention by heat shock proteins
15:30-16:30 Poster session
16:30-16:45 Selected oral communication - Richard Walton (University of Leeds, UK)
Ageing to arrhythmias: canges in cardiac ionic regulation with age
16:45-17:00 Selected oral communication - Desiree Wilks (Manchester Metropolitan University, UK)
Bone strength of the tibia and the radius in master runners, master walkers and sedentary people: a peripheral quantitative computer tomography study
17:00-17:30 Scott Powers (University of Florida, Gainsville, USA)
Exercise-induced cardioprotection against ischemia-reperfusion injury
17:30-18:00 Susan Howlett (Dalhousie University, Nova Scotia, Canada)
An ageing problem of cardiac excitation-contraction coupling: but is this a male-only concern?

Maintenance of muscle mass

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Paul Greenhaff (University of Nottingham, UK)
Sponsor(s)
Merck
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Lars-Eric Thornell (Umea University, Sweden)
Muscle fibre proliferation and remodelling
10:00-10:30 Scot Kimball (Pennsylvania State University, Hershey, USA)
The role of nutrition in stimulating muscle protein accretion at the molecular level
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Martin Flueck (Manchester Metropolitan University, UK)
Focal adhesion kinase controls load-dependent transcript expression in slow oxidative rat muscle
11:15-11:30 Selected oral communication - Matthew MacKenzie (University of Dundee, UK)
Vps34 is activated by an acute bout of resistance exercise
11:30-12:00 Michael Rennie (University of Nottingham, UK)
Exercise and nutrient controlled mechanisms involved in maintenance of the musculoskeletal mass
12:00-12:30 Didier Attaix (INRA de Theix, Saint Genès Champanelle, France)
The ubiquitin-proteasome system in muscle wasting
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Drugs and human performance: mechanisms of action and efficacy of detection

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Organizer(s)
Stephen Harridge (King's College London, UK)
Speakers
14:30-15:00 Carl Sundberg (Karolinska Institutet, Sweden)
From blood doping to EPO
15:00-15:30 Cristiana Velloso (King's College London, UK)
Regulation of muscle mass by growth hormone and IGF-I
15:30-16:30 Poster session
16:30-16:45 Selected oral communication - Cian McGinley (University of Limerick, Ireland)
Pre-supplementation with vitamins C and E does not reduce indices of exercise-induced muscle damage in men
16:45-17:00 Selected oral communication - Paul Loughna (University of Nottingham, UK)
Stretch induced activation of anabolic pathways in C2C12 cells involves ERK activation
17:00-17:30 Fawzi Kadi (Örebro University, Sweden)
Testosterone, muscle and satellite cells
17:30-18:00 Dominic Wells (Imperial College London, UK)
Gene doping: potential and limitations


Focus Topic: Signalling


Pharmacological chaperones

Monday 9 July 2007

Organizer(s)
Christopher Connolly (University of Dundee, UK)
Speakers
09:30-10:00 Karin Römisch (University of Cambridge, UK)
Protein quality control in the endoplasmic reticulum
10:00-10:30 Neil Millar (University College London, UK)
RIC-3: a chaperone for neuronal nicotinic acetylcholine receptors
10:30-10:45 Selected oral communication - Joris Robben (University of Glasgow, UK)
Rescue of V2R mutants in NDI by pharmacological chaperones
10:45-11:00 Selected oral communication - Meritxell Canals (University of Glasgow, UK)
Recovery of a maturation defective mutant of the a1b adrenoceptor by pharmacological chaperones: biochemical, cytological and pharmacological studies
11:00-11:30 Michel Bouvier (University of Montréal, Canada)
Molecular mechanisms of action and therapeutic potential of pharmacological chaperone on misfolded G protein-coupled receptors
11:30-12:00 Ron Kopito (Stanford University, California, USA)
High throughput screening for pharmacological rescue of protein misfolding disorders
12:00-13:00 Lunch, poster viewing and trade exhibition

Elementary properties of exocytosis and endocytosis

Monday 9 July 2007

Organizer(s)
Robert Zorec (University of Ljubljana, Slovenia)
Speakers
09:30-10:00 Ruth Heidelberger (The University of Texas Medical School at Houston, USA)
Neurotransmitter release at a tonic synapse
10:00-10:15 Selected oral communication - Gerald Prescott (University of Liverpool, UK)
Modulation of synaptic exocytosis by Akt phosphorylation
10:15-10:30 Selected oral communication - Hans Schnittler (TU-Dresden, Germany)
The dual role of caveolin-1 in para- and transcellular permeability in endothelial cells
10:30-11:00 Gareth Evans (University of York, UK)
PKA regulation of synaptic vesicle cycling in cerebellar plasticity
11:00-11:30 Robert Burgoyne (University of Liverpool, UK)
Role of Munc18 and Rab proteins in the dynamics of dense-core granule exocytosis
11:30-12:00 Robert Zorec (University of Ljubljana, Slovenia)
Elementary properties of resting fusion
12:00-13:00 Lunch, poster viewing and trade exhibition

Compartmentalized signalling in neurons - part 1

Monday 9 July 2007

12:00-13:00 Lunch, poster viewing and trade exhibition
13:00-14:00 Poster session
14:00-15:00 Plenary Lecture
Tony Pawson (Samuel Lunenfeld Research Institute, Toronto, Canada)
The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
Chair: Melanie Welham (University of Bath, UK)
Organizer(s)
John Challiss (University of Leicester, UK)
Shamshad Cockcroft (University College London, UK )
Paola Pedarzani (University College London, UK)
Sponsor(s)
Biolog Inc.
Eli Lilly
Nanion Technologies
Speakers
15:00-15:30 Roger Tsien (University of California, San Diego, USA)
Imaging glutamate concentrations and new protein synthesis at synapses
15:30-16:00 Carlos Sindreu (University of Washington, Seattle, USA)
Crosstalk between MAP kinase and cAMP during the formation of hippocampus-dependent memory
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Ruth Taylor (University College London, UK)
Role of calcium-stimulated adenylyl cyclases in the modulation of the slow afterhyperpolarisation in hippocampal pyramidal neurons
16:45-17:00 Selected oral communication - Lissa Herron (University of St. Andrews, UK)
The L1 cell adhesion family and their interaction with the 4.1 superfamily
17:00-17:30 Julietta Frey (Leibniz Institute for Neurobiology, Magdeburg, Germany)
Compartmentalization of functional plasticity: the basis for memory formation
17:30-18:00 Kirsty Millar (University of Edinburgh, UK)
Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

Signals and SNARES regulating vesicle exocytosis

Monday 9 July 2007

Organizer(s)
Elizabeth Seward (University of Sheffield, UK)
Speakers
15:00-15:30 Thorsten Lang (Max Planck Institute, Gottingen, Germany)
SNARE proteins and lipid rafts
15:30-16:00 Janet Richmond (University of Illinois, Chicago, USA)
Tomosyn negatively regulates release at the C. elegans neuromuscular junction
16:00-16:30 Coffee/tea break
16:30-17:00 Alan Morgan (University of Liverpool, UK)
Regulation of SNARE function by post-translational modification
17:00-17:30 Bazbek Davletov (MRC Laboratory of Molecular Biology, UK)
Regulation of SNARE fusion machinery by fatty acids
17:30-17:45 Selected oral communication - Nina Vardjan (Celica Biomedical Center, Ljubljana, Slovenia)
Fusion pore opens to subnanometer diameters in resting neuroendocrine cells
17:45-18:00 Selected oral communication - Yashka Manning (University of Aberdeen, UK)
Tumour protein D52: expression in pancreatic b-cell lines and its role in glucose-stimulated insulin secretion

Compartmentalized signalling in neurons - part 2

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
John Challiss (University of Leicester, UK)
Shamshad Cockcroft (University College London, UK)
Paola Pedarzani (University College London, UK)
Sponsor(s)
Biolog Inc
Eli Lilly
Nanion Technologies
Speakers
09:30-10:00 Masanobu Kano (Osaka University, Japan)
Phospholipase Cb as a neuronal coincidence detector
10:00-10:30 David Brown (University College London, UK)
Dynamic regulation of PIP2 and its role in ion channel modulation: regulation of M-type potassium channels
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Carl Nelson (University of Leicester, UK)
Independent detection of inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate in live cells using fluorescent biosensors
11:15-11:45 Giles Hardingham (University of Edinburgh, UK)
Pro-death and pro-survival NMDA receptor signalling require different subcellular pools of calcium
11:45-12:15 Ravi Iyengar (Mount Sinai School of Medicine, New York, USA)
Spatially specified signalling networks in hippocampal neurons
12:15-12:30 General discussion
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Beyond Ca2+ pumps

Tuesday 10 July 2007

Organizer(s)
Ruth Empson (Royal Holloway University of London, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Ernesto Carafoli (University of Padova, Italy)
Plasma membrane calcium pumps and hereditary deafness
10:00-10:30 Emanuel Strehler (Mayo Graduate School, Rochester, USA)
Plasma membrane calcium pumps: structural diversity as basis for functional versatility
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Thomas Jensen (Royal Holloway University of London, UK)
Pre-synaptic plasma membrane Ca2+ ATPase isoform 2a regulates excitatory synaptic transmission in rat hippocampal CA3
11:15-11:30 Selected oral communication - Elizabeth Cartwright (University of Manchester, UK)
The plasma membrane calcium ATPase isoform 4 modulates tumour necrosis factor a-induced apoptosis
11:30-12:00 Stella Elkabes (University of New Jersey, USA)
Role of plasma membrane calcium ATPases in neuronal dysfunction
12:00-12:30 Ludwig Neyses (University of Manchester, UK)
PMCA in signalling
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Molecular scaffolds - dynamics and specificity in signalling complex formation

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Caroline Dart (University of Liverpool, UK)
Miles Houslay (University of Glasgow, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Kjetil Taskén (The Biotechnology Centre of Oslo, Norway)
Spatiotemporal control of cyclic AMP signalling processes by anchored signalling complexes
15:00-15:30 Miles Houslay (University of Glasgow, UK)
Mapping and functional elucidation of partnerships involving signal scaffold proteins that tether cAMP phosphodiesterase-4
15:30-16:30 Poster session
16:30-17:00 Ivan Dikic (Goethe University Frankfurt, Germany)
Ubiquitin signalling pathways
17:00-17:30 Margaret Frame (Beatson Cancer Institute, Glasgow, UK)
Regulation of cell adhesion by integrin signalling to the Arp 2/3 complex
17:30-17:45 Selected oral communication - Martin Cann (Durham University, UK)
A subset of GAF domains are evolutionarily conserved sodium sensors
17:45-18:00 Selected oral communication - Roger Summers (Monash University, Clayton, Victoria, Australia)
Functional domains of the mouse b3-adrenoceptor associated with differential G-protein coupling

Calcium dysregulation in disease

Tuesday 10 July 2007

Organizer(s)
Llewelyn Roderick (University of Cambridge, UK)
Sponsor(s)
Pfizer
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 F. Anthony Lai (University of Cardiff, UK)
Ryanodine receptor-calcium release channel (RyR2) dysfunction in cardiac pathology
15:00-15:30 Xander Wehrens (University of Houston, USA)
Sarcoplasmic reticulum calcium leak and cardiac arrhythmias
15:30-16:30 Poster session
16:30-17:00 Luca Scorrano (Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, Padova, Italy)
Mitofusin-2, mutated in Charcot-Marie-Tooth IIa, links endoplasmic reticulum to mitochondria
17:00-17:30 Llewelyn Roderick (University of Cambridge, UK)
Inositol 1,4,5-trisphosphate-induced Ca2+ release; a master regulator of cardiac physiology
17:30-17:45 Selected oral communication - Yuanzhi Lao (Hong Kong University of Science and Technology, Hong Kong)
Study of the functional role of Bcl-2 family proteins in regulating Ca2+ signalling in apoptotic cells
17:45-18:00 Selected oral communication - Eric Churchill (Stanford University, Palo Alto, California, USA)
Proteasomal alterations in the ratios of two novel PKC isoforms regulates myocardial injury following ischemia/reperfusion

Structure-based drug design - part 1

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Gordon Roberts (University of Leicester, UK)
Sponsor(s)
Pfizer
Speakers
09:30-10:00 Philip Dean (De Novo Pharmaceuticals, Cambridge, UK)
Computational drug design
10:00-10:30 Harren Jhoti (Astex Therapeutics, Cambridge, UK)
Fragment based drug discovery using rational drug design
10:30-11:00 Coffee/tea break
11:00-11:30 Malcolm Walkinshaw (University of Edinburgh, UK)
Ligand discovery using the virtual screening program LIDAEUS
11:30-12:00 Nicolas Moitessier (McGill University, Montreal, Canada)
Development and application of FITTED to the docking of ligands to flexible and solvated proteins
12:00-12:30 Michael Sutcliffe (University of Manchester, UK)
Prediction of drug metabolism by cytochromes P450
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Protein-protein interactions: latest advances in biophysical and theoretical approaches

Wednesday 11 July 2007

Organizer(s)
Brian Austen (St Georges Hospital, London, UK)
Parvez Haris (De Montfort University, Leicester, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Mingyue He (Babraham Institute, Cambridge, UK)
Ribosome display and protein in situ array: cell-free discovery tools for identification of protein binders
10:00-10:30 Assaf Friedler (Hebrew University of Jerusalem, Israel)
Intramolecular vs. intermolecular interactions in the proapoptotic protein ASPP2: a proposed mechanism for regulation of p53-mediated apoptosis
10:30-11:00 Coffee/tea break
11:00-11:30 Richard Jackson (University of Leeds, UK)
Prediction and analysis of protein interaction sites: binding hot-spots in protein–protein and protein–ligand interfaces
11:30-12:00 Hans-Peter Hauri (University of Basel, Switzerland)
Capturing protein interactions in the secretory pathway of living cells
12:00-12:30 Richard Parsons (St George's University of London, UK)
Protein-protein interactions in the formation of the beta-secretase complex in Alzheimer's disease
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Structure-based drug design - part 2

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Organizer(s)
Gordon Roberts (University of Leicester, UK)
Sponsor(s)
Pfizer
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Bill Hunter (University of Dundee, UK)
Picking pockets to feed drug discovery for neglected diseases
15:00-15:30 Thue Schwartz (University of Copenhagen, Denmark)
Molecular efficacy switches in agonists and receptors – how to swap between agonism and inverse agonism in 7TM receptors
15:30-16:30 Poster session
16:30-17:00 Bernd Meyer (University of Hamburg, Germany)
Fragment based screening by STD NMR - From soluble targets to GPCRs
17:00-17:30 David Middleton (University of Liverpool, UK)
Structure-based design of amyloid inhibitors
17:30-18:00 Marc Baldus (Max Planck Institute, Göttingen, Germany)
Membrane protein complexes investigated by solid-state NMR

Cell biology of protein kinase C

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Alastair Poole (University of Bristol, UK)
Peter Parker (CRUK, London, UK)
Sponsor(s)
Wyeth
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Alan Fields (Mayo Clinic, Florida, USA)
Protein kinase CI: oncogene, prognostic marker and therapeutic target
10:00-10:30 Mary Reyland (University of Colorado, Denver, USA)
PKCd and apoptosis
10:30-11:30 Poster session with coffee and tea
11:30-11:45 Selected oral communication - Alessandro Sardini (Medical Research Council, London, UK)
Protein Kinase Ca is retained at the plasma membrane by the multidrug transporter P-glycoprotein
11:45-12:00 Selected oral communication - Senena Corbalan (University of Murcia, Spain)
The C2 domains of classical PKCs are specific PtdIns(4,5)P2-sensing domains
12:00-12:30 Alastair Poole (University of Bristol, UK)
Isoform-specific functions of PKC: the platelet paradigm
12:30-13:00 Alison Michie (University of Glasgow, UK)
Functional significance of manipulating PKCa signalling during lymphocyte development and leukaemogenesis
13:00-14:00 Lunch, poster viewing and trade exhibition

Protein kinase C: from function to drug target

Thursday 12 July 2007

13:00-14:00 Lunch, poster viewing and trade exhibition
14:00-15:00 Plenary Lecture
Frank Sargent (University of East Anglia, UK)
The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
Chair: Stuart Ferguson (University of Oxford, UK)
Organizer(s)
Alastair Poole (University of Bristol, UK)
Peter Parker (CRUK, London, UK)
Sponsor(s)
Wyeth
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
15:00-15:30 Peter Parker (CRUK, London, UK)
PKC control of cell division
15:30-16:00 Michael Leitges (University of Oslo, Norway)
Functional PKC in vivo analysis using deficient mouse models
16:00-16:15 Selected oral communication - Warren Thomas (Royal College of Surgeons in Ireland, Dublin, Ireland)
Aldosterone rapidly activates protein kinase d via a mineralocorticoid receptor/epidermal growth factor receptor trans-activation pathway in kidney cortical collecting duct cells
16:15-16:30 Selected oral communication - Grant Budas (Stanford University, California, USA)
Mitochondrial import of PKC epsilon is mediated by the HSP90-TOM pathway: role in cardioprotective signalling
16:30-17:00 Daria Mochly-Rosen (Stanford University, USA)
Competitive inhibitors and allosteric activators of PKC isozymes; from bench to bedside
17:00-17:30 Lidia Mosyak (Wyeth, Cambridge, USA)
Structure-based optimization of PKC-theta antagonists


Focus Topic: Cardiovascular bioscience


Biochemical and physiological aspects of oxygen sensing

Monday 9 July 2007

Organizer(s)
Peter Rich (University College London, UK)
Jeremy Ward (King's College London, UK)
Speakers
09:30-10:00 Michael Wilson (University of Essex, UK)
Oxygen binding heme proteins
10:00-10:30 Paul Schumacker (Northwestern University, Chicago, USA)
Oxygen sensing by the mitochondrial electron transport chain: role of reactive oxygen species in signal transduction in hypoxia
10:30-11:00 Paul Kemp (Cardiff University, UK)
Potassium channel protein partners: gas sensing in the cardiovascular system
11:00-11:30 Peter Ratcliffe (University of Oxford, UK)
Oxygen sensing by protein hydroxylases
11:30-11:45 Selected oral communication - William Wilkinson (Cardiff University, UK)
Carbon monoxide exerts two different temporal effects on heterologously expressed rat P2X2 receptors in vitro
11:45-12:00 General discussion
12:00-13:00 Lunch, poster viewing and trade exhibition

Cerebrovascular function: changes in health and disease

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Douglas Corfield (Keele University, UK)
Sponsor(s)
Merck
Speakers
09:30-10:00 Edith Hamel (Montreal Neurological Institute, Canada)
Oxidative stress and cerebrovascular dysfunction in neurodegenerative disease
10:00-10:30 Hugh Markus (St George’s Hospital, London, UK)
Genes, endothelial function and cerebral small vessel disease
10:30-11:00 Coffee/tea break
11:00-11:30 Douglas Corfield (Keele University, UK)
Hypoxia and hypercapnia: changes in cerebrovascular regulation during sleep
11:30-12:00 Niels Secher (Copenhagen University Hospital, Denmark)
Central fatigue: muscles work but the brain gets tired
12:00-12:15 Selected oral communication - David Busija (Wake Forest University, Winston-Salem, North Carolina, USA)
Cerebral vascular dilator responses are reduced in Zucker obese rats with insulin resistance
12:15-12:30 General discussion
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Advances in acute stroke research

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Richard Green (University of Nottingham, UK)
Speakers
14:30-15:00 Jean-Claude Baron (University of Cambridge, UK)
Pathophysiology of ischaemic stroke: insights from imaging and implications for therapy
15:00-15:30 Eng Lo (MGH, Harvard University, USA)
Neurovascular pathophysiology in stroke
15:30-16:30 Poster session
16:30-16:45 Selected oral communication - Atticus Hainsworth (St George's University of London, UK)
Examination of the cytoprotective action of NXY-059 in vitro using a neuroblastoma-derived cell-line
16:45-17:00 Selected oral communication - Shalmali Patkar (University of Glasgow, UK)
Acute oestrogenic effects on vascular contractility of middle cerebral artery
17:00-17:30 Richard Green (University of Nottingham, UK)
Pharmacological approaches to stroke: reperfusion certainly, neuroprotection possibly
17:30-18:00 Gary Ford (Institute for Ageing and Health, Newcastle, UK)
Clinical pharmacological issues in the development of acute stroke therapies

Pulmonary hypertension and signalling in pulmonary artery smooth muscle cells

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Alison Gurney (University of Manchester, UK)
Margaret MacLean (University of Glasgow, UK)
Speakers
09:30-10:00 Nick Morrell (University of Cambridge, UK)
Role of BMPR-II mutation in pulmonary arterial hypertension
10:00-10:30 Jason Yuan (University of California, San Diego, USA)
Potassium channels in the regulation of pulmonary artery smooth muscle cell proliferation and apoptosis
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Yvonne Dempsie (University of Glasgow, UK)
Effects of dexfenfluramine on proliferation of pulmonary arterial fibroblasts from mice over-expressing the 5HT transporter
11:15-11:30 Selected oral communication - Shreena Joshi (University of Manchester, UK)
Unexpected effects of KCNQ channel modulators on pulmonary artery
11:30-12:00 Kurt Stenmark (University of Colorado, Denver, USA)
Extracellular ATP: a critical modulator of hypoxia-induced pulmonary artery adventitial fibroblast phenotype
12:00-12:30 Margaret MacLean (University of Glasgow, UK)
Interactions between serotonin, BMPR2 and potassium channels in the development of pulmonary hypertension: an overview
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Collagen cross-linking as a therapeutic target in cardiovascular disease

Wednesday 11 July 2007

Organizer(s)
Cherry Wainwright (The Robert Gordon University, Aberdeen, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Simon Robins (The Rowett Research Institute, Aberdeen, UK)
Biochemistry and functional significance of collagen cross-linking
10:00-10:30 Dinko Susic (Ochsner Clinic Foundation, New Orleans, USA)
Cross-link breakers as a new therapeutic approach to cardiovascular disease
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Emma Hector (The Robert Gordon University, Aberdeen, UK)
Collagen cross-link measurement as an indicator of human carotid artery atherosclerotic plaque vulnerability
11:15-11:30 Selected oral communication - Karen Porter (University of Leeds, UK)
Hypoxic inhibition of human cardiac myofibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling
11:30-12:00 Jason Johnson (Bristol Heart Institute, Bristol, UK)
Matrix metalloproteinases and plaque stability
12:00-12:30 Petri Kovanen (Wihuri Research Institute, Helsinki, Finland)
Mast cells, matrix degradation, and loss of atherosclerotic plaque stability
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Advances in peroxisomal alpha, beta and omega-oxidation

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Organizer(s)
Matthew Lloyd (University of Bath, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Ronald Wanders (University Hospital, Amsterdam, The Netherlands)
Peroxisomes, phytanic acid alpha oxidation and Refsum disease: from enzymology to studies on the toxicity of phytanic acid in patient cells, mutant mice and omega-oxidation
15:00-15:30 Christopher Schofield (University of Oxford, UK)
Structural and mechanistic studies on peroxisomal and related oxygenases
15:30-16:30 Poster session
16:30-17:00 Minne Casteels (University of Leuven, Belgium)
The role of 2-hydroxyacyl-CoA lyase 1, a thiamine pyrophosphate dependent peroxisomal enzyme, in the metabolism of 3-methyl-branched fatty acids and 2-hydroxy straight chain fatty acids
17:00-17:30 Anthony Wierzbicki (St Thomas' Hospital, London, UK)
Clinical aspects of peroxisomal fatty acid metabolism
17:30-17:45 Selected oral communication - Daniel Darley (University of Bath, UK)
Characterisation of recombinant alpha-methylacyl-CoA racemase, a novel prostate cancer target
17:45-18:00 General discussion

Remodelling of blood vessels and cell proliferation

Wednesday 11 July 2007

Organizer(s)
Simon Kennedy (University of Strathclyde, Glasgow, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Christopher Jackson (Bristol Heart Institute, UK)
Is there life after plaque rupture?
15:00-15:30 David Beech (University of Leeds, UK)
Ion channel switching and activation in vascular smooth muscle cell proliferation and neointimal hyperplasia
15:30-16:30 Poster session
16:30-17:00 Qingbo Xu (King's College London, UK)
The role of stem cells in vein graft remodelling
17:00-17:15 Selected oral communication - Graeme Nixon (University of Aberdeen, UK)
Sphingosylphosphorylcholine acts as a pro-inflammatory mediator in vascular smooth muscle cells
17:15-17:30 Selected oral communication - Christopher McCormick (University of Strathclyde, Glasgow, UK)
Effect of prostacyclin analogues on artery function and smooth muscle cell proliferation in the pig and rabbit: implications for drug-eluting stent development
17:30-18:00 Alison Morton (University of Sheffield, UK)
Current challenges in coronary stenting - From bench to bedside

Short lived mediators in the blood vessel wall

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Tim Warner (Queen Mary, University of London, UK)
Sponsor(s)
Merck
Speakers
09:30-10:00 Jane Mitchell (National Heart and Lung Institute, Imperial College London, UK)
Role of NO and Prostacyclin as vaso-active hormones released by the endothelium
10:00-10:30 David Bishop-Bailey (William Harvey Research Institute, London, UK)
Nuclear receptor pathways in the blood vessel wall
10:30-11:30 Poster session with coffee and tea
11:30-11:45 Selected oral communication - Matt Whiteman (Peninsula Medical School, Exeter, UK)
Regulation of nitric oxide bioavailability by hydrogen sulfide: implications for cardiovascular function and human disease
11:45-12:00 Selected oral communication - Mairead Carroll (New York Medical College, Valhalla, New York)
The vascular adenosine-EET pathway exerts a renal protective function
12:00-12:30 Giuseppe Cirino (University of Naples, Italy)
Emerging roles for blood vessel wall hydrogen sulphide in vascular function
12:30-13:00 Arthur Weston (University of Manchester, UK)
What is EDHF?
13:00-14:00 Lunch, poster viewing and trade exhibition

Mediators and mechanisms for keeping myocardial hypertrophy in check

Thursday 12 July 2007

13:00-14:00 Lunch, poster viewing and trade exhibition
14:00-15:00 Plenary Lecture
Frank Sargent (University of East Anglia, UK)
The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
Chair: Stuart Ferguson (University of Oxford, UK)
Organizer(s)
Gillian Gray (University of Edinburgh, UK)
Gary Baxter (Cardiff University, UK)
Speakers
15:00-15:30 Peter Sugden (Imperial College London, UK)
Glycogen synthase kinase 3 as a convergence point in hypertrophic signalling
15:30-16:00 Denise Hilfiker-Kleiner (Medizinische Hochschule Hannover, Germany)
Differential activation of gp130 downstream signalling directs cardiac hypertrophy, collagen metabolism and angiogenesis after myocardial infarction
16:00-16:30 David Bell (Queen’s University Belfast, UK)
Intermedin: a novel counter-regulatory peptide in the heart
16:30-17:00 Gary Baxter (Cardiff University, UK)
Autocrine/paracrine actions of natriuretic peptides in myocardial infarction
17:00-17:15 Selected oral communication - Neil Turner (University of Leeds, UK)
TNFa-induced IL-1 and IL-6 expression in human cardiac fibroblasts: mechanisms and modulation by thiazolidinediones
17:15-17:30 General discussion


Focus Topic: Imaging


Imaging in the life sciences

Tuesday 10 July 2007

Organizer(s)
Craig Daly (University of Glasgow, UK)
Speakers
09:30-10:00 Silvia Arribas (University of Madrid, Spain)
Imaging the vascular wall with confocal microscopy
10:00-10:30 Ian McGrath (University of Glasgow, UK)
Visualization of receptors in native tissue
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Sadaf Mumtaz (University of Liverpool, UK)
Morphological analysis of the rat ureteric terminal arterioles in situ
11:15-11:30 Selected oral communication - Gilles Bru-Mercier (University of Warwick, UK)
Effects of mechanical stretch on inter- and intracellular Ca2+ signals in ultra-thin slices of human myometrium
11:30-12:00 David Becker (University College London, UK)
Gap junctional communication in retinal development
12:00-12:30 Bebhinn Treanor (Imperial College London, UK)
Spatially resolved biochemistry in individual cells by fluorescence lifetime imaging
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

In vivo imaging of small animals using positron emission tomography

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Anthony Davenport (University of Cambridge, UK)
Speakers
09:30-10:30 Michael Welch (Washington University, St Louis, USA)
Overview of small animal PET imaging
10:30-11:00 Coffee/tea break
11:00-11:30 Peter Johnström (University of Cambridge, UK)
Imaging of peptide receptors using microPET
11:30-12:00 Jeffrey Dalley (University of Cambridge, UK)
Imaging animal models of addiction
12:00-12:30 Eric Aboagye (Imperial College, London, UK)
Imaging of cell proliferation
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

Molecular imaging in biology

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Kevin Brindle (University of Cambridge, UK)
Speakers
09:30-10:00 Christopher Contag (Stanford University, USA)
In vivo imaging to advance cell-based therapies for cancer
10:00-10:30 Silvio Aime (University of Turin, Italy)
Lanthanide-based probes for MR-Molecular Imaging investigations
10:30-11:30 Poster session with coffee and tea
11:30-12:00 Klaes Golman (INOGAL Aps Hoersholm, Denmark)
Real molecular imaging of metabolism
12:00-12:30 Kevin Brindle (University of Cambridge, UK)
Detecting tumour responses to treatment using magnetic resonance imaging and hyperpolarised spectroscopy
12:30-13:00 Mathias Hoehn (Max-Planck-Institute for Neurological Research, Cologne, Germany)
Cell tracking using magnetic resonance imaging
13:00-14:00 Lunch, poster viewing and trade exhibition


Focus Topic: Inflammation


Ionic control of endosome and phagosome function

Monday 9 July 2007

Organizer(s)
Janet Allen (University College Dublin, Ireland)
Andres Floto (University of Cambridge, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Sergio Grinstein (University of Toronto, Canada)
The pH gradient and electrical potential of phagosomes: measurement and functional role
10:00-10:30 Paul Luzio (CIMR, University of Cambridge, UK)
The role of calcium and other ions in sorting and delivery in the late endocytic pathway
10:30-11:00 Vladimir Marshansky (Harvard Medical School, Boston, USA)
The V-ATPase a2-subunit as a putative endosomal pH-sensor
11:00-11:30 Anthony Segal (University College London, UK)
The role of the NADPH oxidase in the killing of bacteria and fungi by neutrophils – Replacing the paradigm of free radical damage with ion fluxes and pH optimisation
11:30-12:00 General discussion
12:00-13:00 Lunch, poster viewing and trade exhibition

Spotlight on mechanisms of leucocyte trafficking and transendothelial migration; new opportunities for drug discovery

Monday 9 July 2007

Organizer(s)
Stephen Ward (University of Bath, UK)
Clive Page (King's College London, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Sussan Nourshargh (Imperial College London, UK)
Leukocyte transmigration in vivo: role of endothelial cell junctional molecules and basement membrane remodelling
10:00-10:30 Simon Pitchford (National Heart and Lung Institute, London, UK)
Defining a role for platelets in allergic inflammation
10:30-10:45 Selected oral communication - Helen McGettrick (University of Birmingham, UK)
Differential roles of IL-6 in modulating lymphocyte recruitment across endothelial cells conditioned by dermal or synovial fibroblasts
10:45-11:00 Selected oral communication - Rebecca Lever (The School of Pharmacy, London, UK)
Heparanase induces inflammatory cell recruitment to the peritoneal cavity of the rat
11:00-11:30 David Fruman (University of California, Irvine, USA)
The role of PI3K in lymphocyte motility in vivo
11:30-12:00 Federica Marelli-Berg (Imperial College London, UK)
Novel mechanisms of memory T cell trafficking
12:00-13:00 Lunch, poster viewing and trade exhibition

Mechanisms and drug targets in resolution of inflammation

Monday 9 July 2007

12:00-13:00 Lunch, poster viewing and trade exhibition
13:00-14:00 Poster session
14:00-15:00 Plenary Lecture
Tony Pawson (Samuel Lunenfeld Research Institute, Toronto, Canada)
The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
Chair: Melanie Welham (University of Bath, UK)
Organizer(s)
Stephen Ward (University of Bath, UK)
Luke O'Neill (Trinity College Dublin, Ireland)
Sponsor(s)
Pfizer
Speakers
15:00-15:30 Charles Serhan (Harvard Medical School, Boston, USA)
Novel anti-inflammatory and pro-resolving lipid mediators: resolvins and protectins
15:30-16:00 Adriano Rossi (University of Edinburgh, UK)
Driving resolution of inflammation as a therapeutic strategy
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Gitte Neubauer (Cellzome, Heidelberg, Germany)
Characterization of Novel Phosphoinositide 3-kinase gamma inhibitors: ex-vivo selectivity profiles and cellular functionality
16:45-17:00 Selected oral communication - Fulvio D'Acquisto (Queen Mary University of London, UK)
Annexin-1: a novel target for the therapy of autoimmune diseases
17:00-17:30 Roy Pettipher (Oxagen, Oxford, UK)
Complementary action of the prostaglandin D2 receptors DP and CRTH2 in promoting allergic responses
17:30-18:00 Christopher Buckley (University of Birmingham, UK)
Targeting the stromal microenvironment in chronic inflammation

Mechanisms of inflammatory neurodegeneration

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Guy Brown (University of Cambridge, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Guy Brown (University of Cambridge, UK)
NADPH oxidase, nitric oxide and mitochondria in inflammatory neurodegeneration
10:00-10:30 Nancy Rothwell (University of Manchester, UK)
IL-1 and inflammatory neurodegeneration
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Barry McColl (University of Manchester, UK)
Systemic inflammatory stimulus exacerbates brain damage after experimental stroke via a matrix metalloproteinase-9-dependent mechanism that targets the neurovascular unit
11:15-11:30 Selected oral communication - Jonas Neher (University of Cambridge, UK)
Lipoteichoic acid-induced loss of cerebellar granule cells is mediated by microglia and is dependent on direct neuronal-microglial interaction
11:30-12:00 Michelle Block (NIH, Bethesda, USA)
Extracellular m calpain and microglia-mediated dopaminergic neurodegeneration: mechanisms of reactive microgliosis and progressive neurotoxicity
12:00-12:30 Sean Murphy (University of Washington, Seattle, USA)
Nitric oxide, ischemia and brain inflammation
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Trapping the GAS: from biochemistry to new therapeutics

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Giuseppe Cirino (University of Naples, Italy)
Mauro Perretti (Queen Mary, University of London, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Philip Keith Moore (National University of Singapore, Singapore)
Overview: gases and biology
10:00-10:30 Adrian Hobbs (University College London, UK)
Soluble guanylate cyclase: coordinating gaseous signalling?
10:30-11:00 Coffee/tea break
11:00-11:30 Roberto Motterlini (Northwick Park Institute for Medical Research, UK)
Bioactivity and therapeutic potential of carbon monoxide-releasing molecules (CO-RMs)
11:30-12:00 Stefano Fiorucci (University of Perugia, Italy)
Role of H2S and H2S-derived drugs in gastric and liver protection
12:00-12:15 Selected oral communication - Stephanie Francis (William Harvey Research Institute, London, UK)
Cyclooxygenase-2-derived prostaglandins mediate vascular dysfunction of resistance arteries of endothelial nitric oxide synthase knockout mice in sepsis
12:15-12:30 General discussion
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)

New insights into the anti-inflammatory effects of adenosine A2A receptor agonists

Wednesday 11 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)
Organizer(s)
Mike Trevethick (Pfizer, Sandwich, UK)
Tim Palmer (University of Glasgow, UK)
Sponsor(s)
Pfizer
Adenosine Therapeutics
Speakers
14:30-15:00 Joel Linden (University of Virginia, Charlottesville, USA)
A2A adenosine receptors in tissue protection from reperfusion injury
15:00-15:30 Clive Page (King's College London, UK)
Adenosine receptors and asthma
15:30-16:30 Poster session
16:30-17:00 Michael Freissmuth (University of Vienna, Austria)
Moving out and turning tail: restricted collision of the A2A-adenosine receptor revisited
17:00-17:15 Selected oral communication - Mohammed Safhi (University of Glasgow, UK)
Priming of STATs for cytokine-triggered polyubiquitylation and degradation upon A2A adenosine receptor (A2AAR) expression in vascular endothelial cells
17:15-17:30 Selected oral communication - Adrian Barnard (Pfizer Global Research and Development, Kent, UK)
UK-371,104, a novel adenosine A2A receptor agonist, inhibits acute mediator release in the human neutrophil: comparison with CGS-21,680 and the phosphodiesterase 4 inhibitor, cilomilast
17:30-18:00 Misha Sitkovsky (Northeastern University, Massachusetts, USA)
Hypoxia-adenosinergic regulation of immune response and tissue damage

Oxidative/nitrosative stress

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Ian Megson (UHI Millennium Institute, UK)
Sponsor(s)
Magnettech GmbH
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Barry Halliwell (National University of Singapore)
Biochemistry of oxidative stress
10:00-10:30 Irfan Rahman (University of Rochester, USA)
Oxidative stress and redox regulation of lung inflammation
10:30-11:30 Poster session with coffee and tea
11:30-12:00 Catalina Alarcón De La Lastra (University of Seville, Spain)
Resveratrol as an antioxidant and prooxidant agent: mechanisms and clinical implications
12:00-12:30 Martin Feelisch (University of Warwick, UK)
What role do nitros(yl)ation products play in vivo? More questions than answers
12:30-12:45 Selected oral communication - Anje Cauwels (Ghent University, Belgium)
Differential role for ROS in shock: hydroxyl radicals promote while hydrogen peroxide antagonizes hypotension and mortality
12:45-13:00 Selected oral communication - James Hewinson (University of Bath, UK)
Human P2X7 receptor stimulation results in rapid NADPH oxidase activation and reactive nitrogen species generation
13:00-14:00 Lunch, poster viewing and trade exhibition

Oxidative stress and the endothelium

Thursday 12 July 2007

13:00-14:00 Lunch, poster viewing and trade exhibition
14:00-15:00 Plenary Lecture
Frank Sargent (University of East Anglia, UK)
The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
Chair: Stuart Ferguson (University of Oxford, UK)
Organizer(s)
Roger Wadsworth (University of Strathclyde, Glasgow, UK)
Speakers
15:00-15:30 Mark Kearney (University of Leeds, UK)
Insulin resistance and endothelium dysfunction
15:30-16:00 Patrick Pagano (Henry Ford Hospital, Detroit, USA)
The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?
16:00-16:15 Selected oral communication - Lai Yung (Chinese University of Hong Kong, Hong Kong)
Cranberry juice consumption ameliorates endothelial dysfunction in ovariectomized rats
16:15-16:30 Selected oral communication - Robert Lyon (University of Strathclyde, Glasgow, UK)
Upregulation of aldo-keto reductases AKR1B and AKR1C in aorta: an adaptive response to reactive aldehydes
16:30-17:00 James Leiper (University College London, UK)
Disruption of methylarginine metabolism impairs vascular homeostasis
17:00-17:30 David Newby (University of Edinburgh, UK)
Endothelial dysfunction and atherothrombosis


Focus Topic: Ion Channels


Ion channel trafficking in health and disease

Monday 9 July 2007

Organizer(s)
David Fedida (University of British Columbia, Canada)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Asipu Sivaprasadarao (University of Leeds, UK)
Trafficking of ATP-sensitive potassium channels in health and disease
10:00-10:30 Eckhard Ficker (Case Western Reserve University, Cleveland, USA)
HERG channel trafficking: novel targets in drug-induced long QT syndrome
10:30-10:45 Selected oral communication - Stephen Harmer (University College London, UK)
Characterising the role of abnormal trafficking of KCNE1 in long QT syndrome 5 (LQT5)
10:45-11:00 Selected oral communication - Sarah Mizielinska (University of Dundee, UK)
Are GABAA receptors dynamically trafficked during in vitro models of pathological conditions?
11:00-11:30 James Trimmer (University of California Davis, USA)
Activity-dependent regulation of voltage-gated potassium channels by bidirectional changes in phosphorylation state
11:30-12:00 David Fedida (University of British Columbia, Canada)
Kv channel surface expression is modulated by endocytosis of channels and retrograde trafficking in endosomal compartments by the dynein motor
12:00-13:00 Lunch, poster viewing and trade exhibition

Glutamate receptor trafficking and synaptic plasticity

Monday 9 July 2007

12:00-13:00 Lunch, poster viewing and trade exhibition
13:00-14:00 Poster session
14:00-15:00 Plenary Lecture
Tony Pawson (Samuel Lunenfeld Research Institute, Toronto, Canada)
The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
Chair: Melanie Welham (University of Bath, UK)
Organizer(s)
Jenni Harvey (University of Dundee, UK)
Speakers
15:00-15:30 Graham Collingridge (University of Bristol, UK)
GSK3b regulates synaptic plasticity in the hippocampus
15:30-16:00 Yu Tian Wang (University of British Columbia, Vancouver, Canada)
Hippocampal long-term depression is critical for spatial memory
16:00-16:30 Coffee/tea break
16:30-17:00 Jose Esteban (University of Michigan, USA)
Intracellular machinery for the transport of neurotransmitter receptors at synapses
17:00-17:30 Ana Luisa Carvalho (University of Coimbra, Portugal)
AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-type glutamate receptors: regulation by interacting proteins and alternative splicing
17:30-17:45 Selected oral communication - Jenni Harvey (University of Dundee, UK)
Regulation of AMPA receptor trafficking by leptin
17:45-18:00 General discussion

Biophysical approaches to exploring ion channel structure and dynamics

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Anthony Lee (University of Southampton, UK)
Frank Michelangeli (University of Birmingham, UK)
Sponsor(s)
Pfizer
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Declan Doyle (University of Oxford, UK)
Structural views of the gating process for inwardly rectifying K+ channels
10:00-10:30 Edward Morris (Institute of Cancer Research London, UK)
Structure of the inositol 1,4,5-trisphosphate receptor
10:30-11:00 Coffee/tea break
11:00-11:30 Paul Ronald Selvin (University of Illinois at Urbana-Champaign, USA)
Single-molecule FRET measurements of MscL conformational changes
11:30-12:00 Eduardo Perozo (University of Chicago, USA)
Activation and inactivation gating in potassium channels: insights from structure and dynamics
12:00-12:15 Selected oral communication - Tom Claydon (University of British Columbia, Vancouver, Canada)
A novel rapid inactivation process in cardiac Kv1.5 channels revealed by voltage clamp fluorimetry
12:15-12:30 Selected oral communication - Agata Kranjc (International School for Advanced Studies, Trieste, Italy)
In silico study of putative calcium-binding domains in hBK and hBest1
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

New perspectives of nicotinic receptors: from molecular structure to behaviour

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Susan Wonnacott (University of Bath, UK)
Speakers
14:30-15:00 August Smit (Vrije University, Amsterdam, The Netherlands)
Acetylcholine binding proteins: structural models of the extracellular domain of the nicotinic receptors
15:00-15:30 Neil Millar (University College London, UK)
Molecular pharmacological characterization of neuronal nicotinic acetylcholine receptors: targets for drug discovery and commercially important insecticides
15:30-16:30 Poster session
16:30-17:00 Uwe Maskos (Institut Pasteur, Paris, France)
Nicotinic receptors control dopamine-mediated locomotor behaviours
17:00-17:30 Stephanie Cragg (University of Oxford, UK)
Presynaptic nicotinic receptors and striatal dopamine neurotransmission: a dynamic and endogenous cholinergic filter
17:30-17:45 Selected oral communication - Srinivasan Jayaraman (University of Bath, UK)
a7- and non- a7- containing nicotinic acetylcholine receptors modulate dopamine release in rat medial prefrontal cortex
17:45-18:00 General discussion


Focus Topic: Central Nervous System


Schizophrenia: from genes to treatment

Monday 9 July 2007

Organizer(s)
Judith Pratt (University of Strathclyde, Glasgow, UK)
Robert Hunter (Gartnavel Royal, Glasgow, UK)
Speakers
09:30-10:00 Michael Owen (University of Cardiff, UK)
The genetics of schizophrenia
10:00-10:30 Sabine Bahn (University of Cambridge, UK)
Disease biomarkers in first-onset schizophrenia
10:30-11:00 Judith Pratt (University of Strathclyde, Glasgow, UK)
Modelling prefrontal cortex deficits in schizophrenia: implications for treatment
11:00-11:30 Stephen Lawrie (Royal Edinburgh Hospital, UK)
Imaging genetics in subjects at high risk of schizophrenia
11:30-11:45 Selected oral communication - Catherine Winchester (University of Strathclyde, Glasgow, UK)
Identification of schizophrenia-related genes by global transcriptome analysis of the prefrontal cortex of PCP treated rats
11:45-12:00 Selected oral communication - Simon MacKenzie (Scottish Biomedical, Glasgow, UK)
The Role of PDE11A1 in Schizophrenia
12:00-13:00 Lunch, poster viewing and trade exhibition

Mitochondria and brain function

Monday 9 July 2007

12:00-13:00 Lunch, poster viewing and trade exhibition
13:00-14:00 Poster session
14:00-15:00 Plenary Lecture
Tony Pawson (Samuel Lunenfeld Research Institute, Toronto, Canada)
The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
Chair: Melanie Welham (University of Bath, UK)
Organizer(s)
Richard Porter (Trinity College Dublin, Ireland)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
15:00-15:30 Michael Rowan (Trinity College Dublin, Ireland)
Synaptic memory mechanisms: Alzheimer disease amyloid b protein-induced dysfunction
15:30-16:00 Juan Bolaños (University of Salamanca, Spain)
Control of neuronal survival by the glycolytic pathway
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Andrew Smith (University of Glasgow, UK)
Neurotoxicity of tryptophan metabolites in cultured cerebellar granule neurones
16:45-17:00 Selected oral communication - Joanna Rorbach (Newcastle University, UK)
Translation in human mitochondria: what recycles the ribosomes?
17:00-17:30 Wolfram Kunz (University of Bonn, Germany)
Mitochondrial function in neurodegenerative disorders
17:30-18:00 Kim Krishnan (University of Newcastle, UK)
MtDNA mutations in neurodegenerative disease

Multiple synaptic vesicle retrieval pathways in neuronal physiology

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Michael Cousin (University of Edinburgh, UK)
Speakers
09:30-10:00 Jurgen Klingauf (Max Planck Institute, Göttingen, Germany)
Coupling of exo- and endocytosis: insights from single-vesicle recordings
10:00-10:30 Ege Kavalali (UT Southwestern Medical Center, Dallas, USA)
Multiple vesicle recycling pathways in central synapses and their impact on neurotransmission
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Alice Walmesley (University of Edinburgh, UK)
Functional characterization of the N-terminal domain of Alsin, a protein involved in juvenile onset Motor Neurone Disease
11:15-11:30 Selected oral communication - Carmen Hernandez (University of Puerto Rico at Humacao, Puerto Rico )
Anterograde tracing study and co-localization of NK-1 and Muc3 receptors in the palate of Rana pipiens
11:30-12:00 Leon Lagnado (MRC, Cambridge, UK)
Clathrin-mediated endocytosis is the dominant mechanism of vesicle retrieval at hippocampal synapses
12:00-12:30 Michael Cousin (University of Edinburgh, UK)
Control of slow endocytosis by protein dephosphorylation
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)

Dendritic neuropeptide release

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Mike Ludwig (University of Edinburgh, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Colin Brown (University of Otago, New Zealand)
Inhibition of vasopressin neuron activity by dendritic dynorphin release
15:00-15:30 Quentin Pittman (Calgary Hospital, Alberta, Canada)
Retrograde and autocrine synaptic modulation in the Supraoptic Nucleus
15:30-16:30 Poster session
16:30-17:00 Vicky Tobin (University of Edinburgh, UK)
Mechanisms of dendritic secretion from magnocellular neurons
17:00-17:30 Nancy Sabatier (University of Edinburgh, UK)
The role of intrahypothalamic release of oxytocin in the regulation of appetite
17:30-18:00 General discussion

Mechanisms and modulators of respiratory neurogenesis

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Jeffrey Potts (University of Missouri, Columbia, USA)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Olivier Pierrefiche (University of Picardie Jules Verne, France)
Nitric oxide and respiratory rhythm in mammals: a new candidate for phase transition
10:00-10:30 Daniel Mulkey (Virginia Commonwealth University, Richmond, USA)
TASK channels determine pH sensitivity of serotonergic raphé neurons but do not contribute to central respiratory chemosensitivity
10:30-11:30 Poster session with coffee and tea
11:30-12:00 Ana Abdala (University of Bristol, UK)
Hierarchal organization of a triple oscillator for breathing
12:00-12:30 Alexander Gourine (University College London, UK)
Chemosensory control of respiratory activity: role of purinergic signalling
12:30-13:00 Gordon Mitchell (University of Wisconsin, USA)
Respiratory plasticity induced by intermittent hypoxia: roles of phosphatases and reactive oxygen species
13:00-14:00 Lunch, poster viewing and trade exhibition

Molecular scaffolds symposium: signalling complexes in the synapse

Thursday 12 July 2007

Organizer(s)
Miles Houslay (University of Glasgow, UK)
Caroline Dart (University of Liverpool, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Nicholas Brandon (Wyeth Pharmaceuticals, Princeton, USA)
Dissecting out the role of DISC1 in Schizophrenia through protein-protein interactions
10:00-10:30 Katerina Akassoglou (University of California, San Diego, USA)
Functional interactions between the p75 neurotrophin receptor and phosphodiesterases
10:30-11:30 Poster session with coffee and tea
11:30-12:00 Casper Hoogenraad (Erasmus Medical Center, Rotterdam, The Netherlands)
Activity-dependent regulation of liprina1 degradation by calcium/calmodulin-dependent protein kinase II
12:00-12:30 Seth Grant (Sanger Centre, Cambridge, UK)
MAGUK association signalling complexes: genetic, proteomic and bioinformatic studies of the synapse
12:30-12:45 Selected oral communication - Nin-Nin Chuang (Academia Sinica,Taipei, Taiwan)
Reaction of integrin beta1 with cytokeratin-1 in neuroblastoma NMB7 cells
12:45-13:00 General discussion
13:00-14:00 Lunch, poster viewing and trade exhibition


Focus Topic: Cancer


Checkpoints, signalling, apoptosis and cancer

Wednesday 11 July 2007

Organizer(s)
Heather Wallace (University of Aberdeen, UK)
David Gillespie (The Beatson Institute for Cancer Research, Glasgow, UK)
Sponsor(s)
Merck
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Catrin Pritchard (University of Leicester, UK)
Mouse models for B-Raf induced cancers
15:00-15:30 Helle Ulrich (London Research Institute, UK)
Control of DNA damage tolerance by ubiquitin and SUMO
15:30-16:30 Poster session
16:30-16:45 Selected oral communication - Berndt Muller (University of Aberdeen, UK)
A role for DNA-PK in a checkpoint linking histone gene expression with DNA replication
16:45-17:15 David Gillespie (The Beatson Institute for Cancer Research, Glasgow, UK)
Keeping DNA damage and replication in Chk to counter cancer
17:15-17:45 Alan Clarke (Cardiff University, UK)
Cancer genetics: mouse models of cancer
17:45-18:00 General discussion

Molecular targets for cancer therapy

Thursday 12 July 2007

08:30-09:30 Plenary Lecture
Michael Stratton (Wellcome Trust Sanger Institute, Cambridge, UK)
The Biochemical Society AstraZeneca Award Lecture
BRAF The Busy Life of a New Cancer Gene
Chair: Peter Parker (Cancer Research UK)
Organizer(s)
Heather Wallace (University of Aberdeen, UK)
David Gillespie (The Beatson Institute for Cancer Research, Glasgow, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 BACR Lecture - Margaret Ashcroft (Institute of Cancer Research, London, UK)
Targeting of the hypoxia inducible factor pathway
10:00-10:30 Paul Harkin (Queen's University, Belfast, UK)
Role played by BRCA1 in transcriptional regulation and response to therapy
10:30-11:30 Poster session with coffee and tea
11:30-11:45 Selected oral communication - Tony Corfield (University of Bristol, UK)
O-Glycan regulation of apoptosis and proliferation in colorectal cancer cell lines
11:45-12:00 Selected oral communication - Donna-Marie McCafferty (University of Calgary, Alberta, Canada)
A critical role for toll-like receptor 4 in colitis-associated adenocarcinoma development in interleukin-10-deficient mice
12:00-12:30 Tessa Holyoake (University of Glasgow, UK)
Characterisation of cancer stem cells in chronic myeloid leukaemia
12:30-13:00 Thomas Helleday (University of Oxford, UK)
DNA replication repair: from molecular insights towards new approaches to anti-cancer therapy
13:00-14:00 Lunch, poster viewing and trade exhibition

Cancer chemoprevention

Thursday 12 July 2007

13:00-14:00 Lunch, poster viewing and trade exhibition
14:00-15:00 Plenary Lecture
Frank Sargent (University of East Anglia, UK)
The Biochemical Society Colworth Medal Lecture
The twin-arginine transport system: moving folded proteins across membranes
Chair: Stuart Ferguson (University of Oxford, UK)
Organizer(s)
Heather Wallace (University of Aberdeen, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
15:00-15:30 Gunter Kuhnle (MRC Dunn Human Nutrition Institute, Cambridge, UK)
Interaction of dietary and genetic factors in cancer prevention: the EPIC study
15:30-16:00 Margaret Manson (University of Leicester, UK)
Determining the efficacy of dietary phytochemicals in cancer chemoprevention
16:00-16:15 Selected oral communication - Chi-Feng Hung (Fu-Jen Catholic University, Taipei, Taiwan)
Lycopene inhibits PDGF-BB-induced signalling and migration in human dermal fibroblasts
16:15-16:30 Selected oral communication - Alan Hunt (University of Southampton, UK)
Targeting neuroblastoma; the search for a better ganglioside-based molecular solution
16:30-17:00 Chris Paraskeva (University of Bristol, UK)
COX-2 and colorectal cancer: signalling downstream of COX-2 represents potential novel targets for the prevention/treatment of colorectal cancer
17:00-17:30 Basil Rigas (State University of New York, USA)
Novel agents for cancer prevention based on nitric oxide


Focus Topic: Metabolism


Neuronal control of peripheral glucose metabolism

Monday 9 July 2007

Organizer(s)
Calum Sutherland (University of Dundee, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Alan Cherrington (Vanderbilt University, USA)
Insulin action on the liver in vivo
10:00-10:30 Rachel Batterham (University College London, UK)
Gut peptides and energy balance
10:30-11:00 Mike Ashford (University of Dundee, UK)
Nutrient and hormone sensing by hypothalamic neurons
11:00-11:30 Dominic Withers (University College London, UK)
Transgenic analysis of hypothalamic function
11:30-11:45 Selected oral communication - Roselle Cripps (University of Cambridge, UK)
Early life programming of energy balance
11:45-12:00 General discussion
12:00-13:00 Lunch, poster viewing and trade exhibition

Diabetes, insulin and amino acid metabolism

Monday 9 July 2007

12:00-13:00 Lunch, poster viewing and trade exhibition
13:00-14:00 Poster session
14:00-15:00 Plenary Lecture
Tony Pawson (Samuel Lunenfeld Research Institute, Toronto, Canada)
The Biochemical Society Jubilee Lecture - sponsored by Pfizer
Protein interaction domains and biological complexity
Chair: Melanie Welham (University of Bath, UK)
Organizer(s)
Philip Newsholme (University College Dublin, Ireland)
Simon Eaton (University College London, UK)
Sponsor(s)
Merck
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
15:00-15:30 John (Sean) Brosnan (Memorial University of Newfoundland, Canada)
Homocysteine metabolism in diabetes
15:30-16:00 Philip Newsholme (University College Dublin, Ireland)
Amino acid metabolism, insulin secretion and diabetes
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Terence Herbert (Leicester University, UK)
PERK is an intracellular ATP sensor in pancreatic b-cells
16:45-17:00 Selected oral communication - Daniel Johnson (Univeristy of Manchester, UK)
Glucose-dependent modulation of insulin secretion and intracellular calcium ions by GKA50 – a glucokinase activator
17:00-17:30 Chris Proud (University of British Columbia, Canada)
Amino acids and mTOR signalling in anabolic function
17:30-18:00 Jan Wernerman (Karolinska Institute Stockholm, Sweden)
Muscle free amino acids in the intensive care unit

Nutrient sensing and signalling in epithelial cells

Tuesday 10 July 2007

08:30-09:30 Plenary Lecture
Denis Noble (University of Oxford, UK)
The Physiological Society Paton Lecture
Claude Bernard, the first systems biologist, and the future of physiology
Chair: David Eisner (University of Manchester, UK)
Organizer(s)
Maynard Case (University of Manchester, UK)
Soraya Shirazi-Beechey (University of Liverpool, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
09:30-10:00 Soraya Shirazi-Beechey (University of Liverpool, UK)
Intestinal glucose sensing and regulation of glucose absorption
10:00-10:30 Arthur Conigrave (University of Sydney, Australia)
Physiological significance of L-amino acid sensing by extracellular Ca2+-sensing receptors
10:30-11:00 Coffee/tea break
11:00-11:15 Selected oral communication - Karim Roder (Heriot-Watt University, Edinburgh, UK)
In HepG2 the LXR-responsive elements (LXREs) in the promoters of fatty acid synthase (FAS) and its transcriptional activator, SREBP-1c, respond differently to RXR ligands
11:15-11:30 Selected oral communication - Bruno Reynolds (University of Oxford, UK)
Amino acid transporters and cell signalling in a Drosophila cell line (Schneider (S2) cells)
11:30-12:00 Helen Raybould (University of California, USA)
How does your gut taste? Nutrient detection in the wall of the gastrointestinal tract
12:00-12:30 John McLaughlin (University of Manchester, UK)
Long chain fatty acid sensing in the gastrointestinal tract
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)


Focus Topic: Bacteria


Understanding the enemy: current research in TB

Tuesday 10 July 2007

12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Michael Joyner (Mayo Clinic College of Medicine, USA)
The Physiological Society Michael de Burgh Daly Lecture
A sympathetic view of the sympathetic nervous system and human blood pressure regulation
Chair: Prem Kumar (University of Birmingham, UK)
Organizer(s)
Stephen Busby (University of Birmingham, UK)
Gurdyal S. Besra (University of Birmingham, UK)
Sponsor(s)
Proceedings (invited speakers) will be published in Biochemical Society Transactions
Speakers
14:30-15:00 Stephen Gillespie (University College London, UK)
Tuberculosis: evolution in millennia and minutes
15:00-15:30 Stewart Cole (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
Prospects for new tuberculosis drugs
15:30-16:30 Poster session
16:30-17:00 Philip Butcher (St. George's Hospital, University of London, UK)
Probing host-pathogen interactions, persistence and drug tolerance in Mycobacterium tuberculosis using microarrays
17:00-17:30 Gurdyal Besra (University of Birmingham, UK)
Structure, function and biosynthesis of the Mycobacterium tuberculosis cell wall: the identification of new drug targets
17:30-17:45 Selected oral communication - Luke Alderwick (University of Birmingham, UK)
Identification of a novel arabinofuranosyltransferase AftB involved in a terminal step of cell wall arabinan biosynthesis in Corynebacterianeae, such as Corynebacterium glutamicum and Mycobacterium tuberculosis
17:45-18:00 General discussion

How microbes keep themselves clean: bacterial resistance to xenobiotics

Wednesday 11 July 2007

08:30-09:30 Plenary Lecture
Arthur Christopoulos (Monash University, Victoria, Australia)
The British Pharmacological Society ASCEPT Lecture - sponsored by Merck
New tricks for old dogs: allosteric modulation of G protein-coupled receptors
Chair: Steve Hill (University of Nottingham, UK)
Organizer(s)
Steve Busby (University of Birmingham, UK)
Speakers
09:30-10:00 Peter Bennett (University of Bristol, UK)
Plasmid encoded drug resistance
10:00-10:30 Peter Hawkey (University of Birmingham, UK)
Molecular epidemiology of clinically significant antibiotic resistance genes
10:30-11:00 Coffee/tea break
11:00-11:30 Richard Brennan (University of Texas, USA)
Just how does a single protein recognise all of those drugs?
11:30-12:00 Vassilis Koronakis (University of Cambridge, UK)
Structure and function of tripartite pumps for bacterial toxin export and multidrug efflux
12:00-12:30 General discussion
12:30-13:30 Lunch, poster viewing and trade exhibition
13:30-14:30 Plenary Lecture
Thomas Bolton (St Georges Hospital, London, UK)
The Physiological Society Annual Review Prize
Smooth muscle excitation
Chair: Ole Petersen (University of Liverpool, UK)


Focus Topic: Education


Research - Teaching linkage: enhancing graduate attributes

Monday 9 July 2007

Organizer(s)
Kevan Gartland (Glasgow Caledonian University, UK)
Edward Wood (University of Leeds, UK)
Speakers
15:00-15:30 Alan Jenkins (Oxford Brookes University, UK)
Strategies to ensure effective teaching research links in the biosciences
15:30-16:00 Neil MacFarlane (Nottingham Trent University, UK)
Demand led courses - a case study: BSc (Hons) Applied Biomedical Science
16:00-16:30 Coffee/tea break
16:30-16:45 Selected oral communication - Adam Bostanci (British Library, London, UK)
On the launch of UK PubMed Central
16:45-17:00 Selected oral communication - Dave Lewis (Interdisciplinary Ethics Applied CETL, University of Leeds, UK)
Embedding ethics into the undergraduate and postgraduate curricula in biological sciences
17:00-17:30 Stephen DiCarlo (Wayne State University, Detroit, USA)
Research on activities to improve pedagogy
17:30-18:00 Kevan Gartland (Glasgow Caledonian University, UK)
Investigating how research-teaching linkages influence life sciences graduate attributes